Powered by four 220 hp Renault 6Q-02 six-cylinder air-cooled inverted in-line engines, the aircraft first flew on November 18, 1937. After receiving its CofA in 1938 the aircraft was subsequently registered F-AQJB to Régie Air Afrique, who used the aircraft, baptized Ville de Bamako (a city in Mali) at their Algiers (Algeria)-Niamey (Niger) route. The airline wanted more examples, however, military aircraft manufacturing had a higher priority.
On request of the military a second aircraft was produced, designated Potez 662, this twelve-seat transport aircraft had a reinforced structure and was powered by four 660 hp Gnome-Rhone 14M-5 fourteen-cylinder twin-row radial engines; it was first flown on July 26, 1938. It was requisitioned by the Vichy government in July 1940 and registered F-ARAY it was used as a liaison aircraft.
When General Charles Huntziger became Secretary of War, the Potez 662 became his personal transport, in which he died when the aircraft crashed on Mount Aigoual in the Massif Central, France, on November 1, 1941.