The F.110 had glazed panels in the sides and bottom of the fuselage to improve its visual reconnaissance capabilities. and had provision for a camera and radio equipment. The 260 hp Salmson 9Z radial piston engine was unusual in being liquid-cooled, and the radiator was located under the fuselage just forward of the main unit of the fixed tail skid landing gear. Armament consisted of one fixed and two trainable 0.303 in (7.7 mm) machine guns, and light bombs carried under the fuselage.
The F.110 prototype was evaluated during 1921, revealing good performance and handling characteristics, and the French army placed two orders totaling 175 aircraft. The first F.110s entered service in 1922, but operational flying revealed that the Farman engineers had inadequate grasp of the nature of aluminum alloy. There were a number of accidents as a result of structural failure. and this meant that total deliveries were reduced to just fifty extensively modified aircraft. In the event, the F.110 remained in first-line service for little more than one year."